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The hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production, is known to be affected by metabolic status, obesity, and insulin resistance

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Its structure is built to engage three separate receptor types in one molecule, a departure from the single-target design of earlier-generation compounds a design shift also explored in our retatrutide vs tirzepatide comparison, which looks at dual- and multi-agonist peptides more broadly