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GLP-1 receptor agonism → glucose-dependent insulin secretion GIP receptor agonism → additional insulinotropic and adipose signaling Glucagon receptor agonism → hepatic energy expenditure and lipolysis Balanced tri-agonism → energy expenditure alongside reduced energy intake Fatty-acid conjugation → albumin binding and extended plasma half-life Core Areas of Scientific Investigation Multi-Receptor Agonist Design: it is studied as a model for balancing potency across three receptors within one peptide sequence without producing unopposed glucagon signaling

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Maintain light physical activity: Gentle walking helps gastric motility and reduces constipation without placing excessive demands on energy reserves