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By restoring and enhancing GLP-1 pathway activity, medications like semaglutide may interrupt this cycle at multiple points, reducing both cortisol-driven appetite and centralized fat accumulation
![PDF] Once-Weekly Semaglutide in Adults with Overweight or Obesity](https://ai2-s2-public.s3.amazonaws.com/figures/2017-08-08/071f41b3896aa3bfba9fc3306243558125aee47b/10-Table3-1.png)
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![PDF] Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial](https://figures.semanticscholar.org/898978c1b0543b943d605e293f5296fb7568cee7/12-Table3-1.png)
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