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The table lists 3 to 7 percent over 12 weeks for phentermine, 2.5 to 3.5 percent over 24 weeks for orlistat, 5 to 9 percent over 56 weeks for naltrexone-bupropion, and 2 to 3 percent for off-label metformin in insulin-resistant populations
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Landmark trials including STEP 1 and STEP 2 demonstrated that once-weekly subcutaneous semaglutide produced 15–18% body weight reduction over 68 weeks when doses were maintained consistently on a seven-day schedule
