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Insulin receptor substrate 1 (IRS-1) is a critical mediator of insulin signal transduction in insulin-sensitive tissues [83]

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The main genetic abnormalities - del15q, mUPD, and imprinting center defect - can all be identified using Comparative Genome Hybridization (aCGH) in combination with methylation-specific multiplex ligation-dependent probe amplification analysis (MS-MLPA)