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GLP-1 receptor activation, the same pathway used by semaglutide, helps slow gastric emptying so you feel fuller longer and reduces appetite signals
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6 Further along the gut, nutrients reaching the distal small intestine trigger GLP-1 and PYY release, which further slows gastric emptying as part of a negative feedback loop researchers call the "ileal brake." 7 Evidence that GLP-1-based therapies also slow the colon itself is thinner and more mixed than the gastric-emptying evidence, so treat that part of the picture as less settled
