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The final model of GLP-1R–PF-06372222–Fab7F38 contained 29–257, 315–474 of GLP-1R, 258–314 residues of rubredoxin, and chain B and chain C of Fab7F38
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Unlike tirzepatide (which also engages GIP receptors), semaglutide specifically targets GLP-1 receptors, delivering a powerful effect on metabolism
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