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The increase in use of GLP-1s is alarming for two reasons: (1) The first reason that the increase in use of GLP-1 drugs is concerning is their little-known long-term side effects and potentially unknown short-term side effects
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Since cannabis itself is often ingested orally (edibles, capsules, tinctures), GLP-1RA-induced delayed gastric emptying might prolong time to onset of cannabis effect, contributing to potential for unintentional overuse if patients re-dose before initial effects manifest.[1][2] Evidence for direct GLP‑1–cannabinoid interactions Emerging literature suggests additional interactions beyond motility
