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Importantly, exendin and exenatide have been found to suppress interferon gamma (IFN‐γ), IL‐17, interleukin‐2 (IL‐2) and IL‐1β expression in vitro human islets [98], suppressed IL‐1β expression in vitro β‐cell assays of humans, mice, and rats [99], and decreased TNF‐α and IL‐1β in LPS‐treated human monocytes/macrophages [100]

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