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Side Effects: Participants experienced mild and moderate side effects, with no serious events Phase 1b/2a Injectable Trial 1.25 mg (after 20 weeks): Patients lost 9.7% of their starting weight 5 mg (after 28 weeks): Participants lost 16.2% of their starting weight 20 mg (36 weeks): Participants lost 22.0% of their starting weight 60 mg (36 weeks): Participants lost up to 24.3% of their starting weight Side Effects: Mainly stomach-related side effects Summary from ADA 2025 & The Lancet Combined oral and injection results confirm: Patients lost 10% to 24% of their starting body weight, depending on dose The medication has the same safety profile as other GLP-1 drugs Weight loss results were the same or better than current GLP-1 drugs Summary Amycretin is a weight loss drug being developed by Novo Nordisk
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14) and requires fewer critical conserved nodes in the top half of the TM bundle (Supplementary Fig
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