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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys: Cell Reports Medicine
In palmitic acid-stimulated mouse podocytes, berberine upregulates AMPK and PGC-1α, which reduces mitochondrial fragmentation, decreases mitochondrial ROS production, and enhances ATP levels, ultimately improving mitochondrial dynamics and function [191]
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