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There was a statistically significant reduction in the primary endpoint, which was a composite of cardiovascular death or worsening HF events, with an RRR of 33%.8 SUMMIT also demonstrated significant improvements in patient-reported outcomes: at 52 weeks, tirzepatide increased KCCQ-CSS, with a between-group mean difference of 6.9 points, and increased 6-minute walk distance, with a between-group mean difference of 18.3 m.8 Notably, in patients with obesity and HFpEF, these dedicated HFpEF trials showed a significant improvement in patient-reported outcomes measured by the KCCQ-CSS
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