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Heart Failure Outcomes GLP-1 agonists show promise in heart failure, particularly HFpEF, as follows: STEP-HFpEF and STEP-HFpEF DM: Semaglutide improved KCCQ scores (+16.6 points), reduced HF hospitalizations (HR 0.79), and enhanced physical function in HFpEF patients with or without T2DM [11,46]

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More serious but rare adverse effects can include pancreatitis, gallbladder problems (particularly with rapid weight loss), thyroid-related issues, and in people with type 2 diabetes using semaglutide, potential worsening of diabetic retinopathy