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Peripherally administered PYY(3-36) crosses the blood-brain barrier to act on Y2R-expressing NPY/AgRP neurons in the hypothalamic arcuate nucleus, inhibiting their activity and enhancing satiety signals (60, 87, 88)

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Patients start at 1.5 mg daily for the first month and increase every 30 days through 4 mg, then 9 mg, reaching the maintenance dose of 25 mg