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Increased PIP3 level leads to activation of the phosphoinositide-dependent kinase 1 (PDK1), and activates the v-akt murine thymoma viral oncogene homolog 1 (AKT) through the PH domain of AKT [110, 111]

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Semaglutide and Cardiovascular Outcomes In Patients With Obesity and Prevalent Heart Failure: A Prespecified Analysis of the SELECT Trial