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When to contact your provider about dosing changes Contact within 1 to 2 weeks if: You're considering stopping or changing your dosing schedule due to cost Nausea is severe enough that you're skipping doses You've already started alternate-day dosing and want to know how to resume daily dosing safely You're not seeing any appetite suppression or weight loss after 6 to 8 weeks on a stable dose Contact same-day if: Vomiting is severe enough that you can't keep liquids down for more than 12 hours You have severe upper abdominal pain (possible pancreatitis) You have symptoms of dehydration (dizziness, dark urine, confusion) Do not: Change your dosing schedule without provider guidance Take a double dose to "make up" for skipped days Split tablets (Rybelsus tablets are not designed to be split and doing so destroys the SNAC coating that enables absorption) Switch between oral and injectable formulations without a new prescription and dosing plan Dosing changes, even ones that seem minor, affect how the medication works and how your body responds

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