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Why It Matters This is the first human study to show that GLP-1 medications may help the body burn visceral fat more actively — not just reduce calories in.That means the weight loss benefits could be coming from both appetite control and a metabolic boost

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Cardiovascular Safety Studies With DPP-4 Inhibitors The “Clinical Guidance for Pharmaceutical Industry–Diabetes Mellitus—Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes” established by the FDA in 2008 as a consequence of adverse safety signals of rosiglitazone has set up the requirement for novel diabetes medications to prove cardiovascular safety of these substances in comparison to standard therapy under glycaemic equipoise