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Pharmacological agents: GLP-1 agonists, DPP-IV inhibitors, and pramlintide While the beneficial effect of GLP-1 agonists and DPP-IV inhibitors on glycemia in type 2 diabetes has been attributed to glucose-dependent insulinotropic and glucagonostatic properties, GLP-1 agonists also slow gastric emptying and that is, at least in some cases, an important mechanism by which they lower postprandial glucose excursions
