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Rats developing IR due to high-fat diet (HFD) feeding showed improved HOMA-IR values and blood glucose levels in oral glucose tolerance test (oGTT) and more active glucagon-like peptide-1 (GLP-1) and insulin in plasma ( DPP4 deficiency in mice Most of the observations already described in deficient rats are also true in whole-body DPP4-KO mice
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However, it goes without saying that anything that offers potential benefits—whether ‘natural’ or pharmaceutical—poses the risk of side effects and serious interactions
