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gip and glp 1 receptors Two incretin hormones GLP-1 GIP: Comparison of their actions in insulin secretion and β cell preservation TrimRX | GLP-1 vs GIP: –
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Unlike in the phase 2 trial with dulaglutide as a comparator, where the 15 mg dose of tirzepatide was used upfront, in the SURPASS 1 trial, a lower starting dose and slower monthly escalation was used to improve gastrointestinal tolerability