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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

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[12] [13] Endogenous GLP-1 has a very short half-life, typically 1–2 minutes, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)