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In line with these observations, recent findings indicate that the appetite-suppressing actions of GLP-1RAs may also be mediated through receptors located in circumventricular organs outside the BBB

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The GLP-1 component activates hepatic AMPK/SIRT1 pathways, which inhibit SREBP-1c, a master regulator of de novo lipogenesis, thereby reducing hepatic triglyceride synthesis (37, 38)