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In the non-T2D cohort, total costs were ¥7 595 634 compared with ¥6 926 474 for the comparator, with incremental gains of 0.126 QALYs and 0.044 life-years, resulting in an ICER of ¥5 300 580/QALY
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See the retatrutide dosing protocol for the titration steps trials linked to lower GI side-effect rates