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Average effects (from the PIONEER trial program, Aroda et al., Diabetes Care 2019, and follow-ups): A1C reduction of 0.6 to 1.4% depending on dose Weight loss of 1 to 4 kg over 26 to 52 weeks at 14 mg Cardiovascular safety similar to injectable semaglutide The drug must be taken at a specific time, with strict water and fasting rules covered in detail below
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