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If side effects become severe at a particular dose, the retatrutide titration schedule allows for a dose hold rather than discontinuation, meaning tolerability issues can be addressed without abandoning treatment entirely

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PYY 3–36 , a truncated peptide agonist derived from dipeptidyl peptidase IV (DPPIV)-mediated proteolysis of full-length PYY 1–36 , is of particular interest as it binds preferentially to the anorectic neuropeptide Y2-R 10,11,12,17,25