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Overnight-fasted mice were divided into groups
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Limited clinical data suggest that homozygous carriers of the minor allele may have reduced weight loss and HbA1c reduction with GLP-1 agonists, though the sample sizes in published studies are small (n 30% Target UACR reduction: expect 25-35% reduction from baseline with dual therapy Hydration counseling is critical: patients with CKD are vulnerable to AKI from dehydration caused by GI side effects