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Interestingly, even the signaling of GIPR toward cAMP synthesis seems to depend on βarrestins, but in the opposite manner, to the one theoretically expected: efficacy of GIPR at producing cAMP diminishes, instead of increasing, in the absence of βarrestins [42], which indicates a profound effect of βarrestins on GIPR signaling beyond receptor desensitization (Figure 2, right)
