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To examine molecular mechanisms of this phenomenon, exendin (9–39)—specific inhibitor of GLP-1 receptor, Rp-cAMP—the cAMP inhibitor, PI3 K inhibitor LY294002 or p44/42 mitogen-activated protein kinase inhibitor UO126, were given concomitantly with GLP-1 + VP infusion
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However, both insulin resistance and hyperinsulinemia can contribute to cognitive impairment in adults, highlighting impaired tissue sensitivity to insulin as a pathogenic mechanism in AD [29]
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