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The delayed gastric emptying induced by semaglutide can increase gastric pressure and volume, potentially promoting reflux of gastric contents into the esophagus
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A larger 228-adult double-blind, randomized, placebo-controlled, dose-ranging trial in functional constipation (Rome III criteria) tested 1 × 10⁹ and 1 × 10¹⁰ CFU per day for 28 days against placebo