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Having difficulty putting on dentures Severe symptoms could consist of: Decaying teeth Dry skin and eyes Joint discomfort and skin rash Causes of Dry Mouth (Xerostomia) A few reasons for dry mouth are: Many prescription and over-the-counter medications, such as those for depression, nausea, pain management, anxiety, acne, allergies, hypertension, asthma, cold, obesity, psychotic conditions, and Parkinson’s disease frequently cause dry mouth as a side effect