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Introduction Alzheimer’s disease (AD), a global public health priority, is the most common neurodegenerative disease ( Some human and animal studies show that insulin can accelerate the clearance level of Aβ in the brain and affects the phosphorylation of tau protein, meanwhile, enhances the synaptic activity and plasticity of neurons ( Glucagon-like peptides 1 (GLP-1), derived from intestinal L cells, is an incretin hormone