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However, insulin-metformin (−0.9%), insulin-AGIs (−0.4%), and insulin-DPP4I (−0.4%) combinations had revealed a less significant change in A1C compared to insulin-SU combination therapy.[138] Furthermore, a meta-analysis comprising 17 RCTs reported a significantly lower A1C in SU groups (in combination with insulin) compared with placebo (0.46% lower
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