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GLP-1R populations in the nucleus accumbens (ACBs), paraventricular nucleus (PVH), lateral hypothalamus (LHA), and ventral tegmental area (VTA) are involved in food choice, reward, and taste aversion [40]
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Data Animal Data In embryo-fetal development studies, sitagliptin administered to pregnant rats and rabbits during organogenesis (gestation day 6 to 20) did not adversely affect developmental outcomes at oral doses up to 250 mg/kg (30-times the 100 mg clinical dose) and 125 mg/kg (20-times the 100 mg clinical dose), respectively, based on AUC
