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Condylomata Acuminata (Genital Warts) 2+ Estimulan la liberación de insulina Resultado: ↑ respuesta de las células beta a la glucosa Efectos extrapancreáticos: ↑ Sensibilidad tisular a la insulina ↓ Producción hepática de glucosa Farmacocinética A continuación se describe la farmacocinética de las sulfonilureas de 2da generación: Absorción: buena absorción por vía oral Distribución: ampliamente unidas a proteínas Metabolismo: Hepático a través del sistema citocromo P450 ( CYP2C9 CYP2C9 A cytochrome p-450 subtype that has specificity for acidic xenobiotics