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“With insulin, there is risk of weight gain, for hypoglycemia, and there’s more treatment burden and need for glucose monitoring.” GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforglipron’s effects on heart health
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Nausea, vomiting, or constipation in early weeks can paradoxically mask true appetite suppression—your appetite may be reduced, but GI discomfort makes eating uncomfortable
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