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Although the therapeutic benefits have yet to be reported for a specific GLP-1/antisense molecule designed to deliver a therapeutically-relevant antisense, the data suggest that GLP-1R is a suitable vector for in vivo tissue targeting, cellular internalization, and intracellular deposition of a cargo moiety

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CagriSema, also investigational in the US, produced 22.7% weight loss at 68 weeks against 2.3% on placebo in REDEFINE 1 12