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Second, endothelial lining GLP-1 promoted better endothelial lining of blood vessels through activation of PKA-P13K/AKT-endothelial nitric oxide synthase (eNOS) pathway

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These abnormalities increase the risk of cardiovascular disease, which is the leading cause of death among people with type 2 diabetes.In addition to obesity, other factors that contribute to insulin resistance include a sedentary lifestyle, a diet high in processed foods and sugar, and certain medications, such as glucocorticoids