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Projections to the area postrema and the other circumventricular organs such as the median eminence or the subfornical organ are very sparse (Llewellyn‐Smith et al., 2011), so one might argue that these receptors are targets for gut‐derived GLP‐1, but not brain‐derived GLP‐1, leaving the separation between the peripheral and central GLP‐1 system intact
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