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For instance, in April 2026, according to data published by Lancet under the journal of public health in Germany, Germany's public health system faces challenges despite high spending, with rising rates of lifestyle-related diseases like obesity, smoking, and heart disease

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ActRII: activin type II receptors, T2D: type 2 diabetes, 6 MWD: 6-minute walk distance, GLP-1/GIP: glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide, SARMs: selective androgen receptor modulators, DMD: Duchenne muscular dystrophy, GLP-1RAs: GLP-1 receptor agonists, IGF-1: insulin-like growth factor, CV: cardiovascular Conclusions Skeletal muscle wasting is a frequent and clinically significant complication in patients with T2D and obesity, which is exacerbated by chronic inflammation, insulin resistance and metabolic dysregulation