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[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas

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Research on semaglutide found that constipation lasts around 47 days on average