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We found here that agonist trafficking properties, as well as insulin secretion, mirrored ฮฒ-arrestin recruitment propensity, contrasting with some 14,33 (but not all 34 ) previous work suggesting that ฮฒ-arrestins do not impact GLP-1R trafficking 14,34,35 , as well as reports of coupling of GLP-1R to insulin secretion via ฮฒ-arrestin-1 14 (although not ฮฒ-arrestin-2 60 )
