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reported a randomized cross-over trial that evaluated the additive effect of continuous infusion of GLP-1 and a TZD, pioglitazone, in patients with type 2 diabetes

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This echoes the findings of a 2013 review, which found “neither firm evidence in favor of this hypothesis nor evidence strong enough to rule out any such increased risk.” Recent research also points to a link between the GLP-1 receptor agonist semaglutide and worsening diabetic retinopathy (DR)