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In the SURPASS-2 trial, patients with type 2 diabetes demonstrated not only substantial weight reduction but also a mean decrease of 2.3% in glycated hemoglobin, highlighting significant improvements in both glycemic control and adiposity-related endpoints [22]

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The most significant published data come from a Phase 2 trial published in The New England Journal of Medicine (Jastreboff et al., 2023), which evaluated retatrutide across multiple doses in adults with obesity or overweight