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2 Despite this substantial burden, noninvasive evaluation of liver fibrosis, the most important prognostic determinant in MASLD, remains inconsistently implemented in primary care and endocrine practice
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SGLT2is reduce oxidative stress by activating SIRT1/AMPK and inhibiting Akt/mTOR, thus collectively contributing to improved cellular energy efficiency, increased resistance to oxidative damage, and ultimately cardio- and renoprotection (reduced blood volume and blood pressure, promotion of diuresis and natriuresis, and glycosuria), especially beneficial in HF cases where excessive fluid can place additional strain on the heart [96,97]
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