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Obesity Disease Burden and Population Health ROI Framework Economic Cost of Obesity, Comorbidity Cascade, and GLP-1 Pharmacotherapy Value-Based Evidence Reshape Global Treatment Investment The Global Obesity Forum estimated total annual economic costs of obesity at USD 4.32 trillion annually in 2025 , representing 2.92% of global GDP and exceeding the full economic output of Germany

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At the same time, as the pleiotropic effects of GLP-1RAs are gradually exhibited, their molecular mechanism, besides lowering blood glucose, is gaining increasing attention