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The science of slowed gastrointestinal motility GLP-1 receptor agonists act on the gut–brain axis and are known to slow gastric emptying and overall gastrointestinal transit , contributing to early satiety and appetite suppression.¹ As intestinal transit slows, the colon has more time to absorb water from stool , leading to hard, dry stools that are difficult to pass .¹ Constipation is a common, dose-related adverse effect listed in FDA prescribing information for both Wegovy® (semaglutide) and Zepbound® (tirzepatide) and is most frequently reported during dose escalation , with improvement over time.²,³ Step-by-Step MD Protocol for Relief 1
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Apart from the regulatory landscape that favors the development of biosimilars, rising cost-cutting measures in healthcare are contributing to the growth of the market
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