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In a placebo-controlled trial, weekly subcutaneous semaglutide led to larger reductions in BMI (−16.1% with semaglutide and +0.6% with placebo), body weight (−15.3 kg with semaglutide and +2.4 kg with placebo), waist circumference, glycated hemoglobin levels, lipid parameters (excluding HDL), and alanine aminotransferase at 68 weeks versus placebo [14]
