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Therefore, BAT has essential physiological roles in the regulation of adaptive thermogenesis, lipid and glucose homeostasis, as well as crosstalk with other metabolic organs to modulate systemic metabolism

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In Donor+Cas9 treated mice, these markers were comparable to those observed in mice fed with normal fat diet (Normal Diet) over 24 weeks, demonstrating a prolonged anti-diabetic effect from in vivo genome editing (Fig