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Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of β-arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]
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DOI : 10.1016/S0140-6736(26)00305-3.
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