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Dose-dependent pancreatitis risk associated with GLP-1 agonists | Journal of Diabetes & Metabolic Disorders | Springer Nature Link

M., Vervoort, G

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(NCBI) Think of GLP-1 signalling as an “appetite brake + pacing” system: Brain: appetite and reward modulation Gut: slower gastric emptying Pancreas: insulin secretion (glucose-dependent) and reduced glucagon secretion (context-dependent) The critical factor is that the lack of appetite typically leads to a caloric deficit